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沈 旭  教授
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电话: 021-50806918
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传真: 021-50806918
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E-mail: xshen@mail.shcnc.ac.cn
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  个人简介
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    1995年中国科学院上海药物研究所获博士学位。1995-1997年中国科学院福建物质结构研究所博士后研究，出站后到上海同济大学任副教授，1999-2001年日本大阪药科大学生物物理化学系JSPS（日本学术振兴会）特别研究员；随后，去美国康奈尔大学医学院开展分子生物学方面的研究工作。2002年被上海药物研究所聘为研究员和博士生导师。2005年获国家杰出青年科学基金。作为项目和课题负责人先后主持国家“863”项目、“973”子课题、“国家自然科学基金”、“上海市重点基金”等多项。发表学术论文80余篇，申请国内外专利20余项，获上海市科技进步一等奖。现任中国科学院上海药物研究所研究员、博士生导师、课题组长、所学位评定委员会委员、所职称评定委员会委员、华东理工大学药学院教授和博士生导师。
   

研究方向
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    近年来从事的科研工作涉及结构生物学、生物物理化学以及药物设计领域。主要研究方向为生物物理化学和分子药理学。
   

获奖成果
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代表性论著
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1."Conformational transition pathway in the allosteric process of human glucokinase", Zhang J, Li C, Chen K, Zhu W, Shen X*, Jiang HL*, Proc Natl Acad Sci USA.2006,103,13368-73.

2. "Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations", Chen S, Hu T, Zhang J, Chen J, Chen K, Ding J, Jiang HL, Shen X*, J Biol Chem. 2008, 283, 554-564.

3.“The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis”, Hu T, Wu D, Chen J, Ding J, Jiang H*, Shen X*. J Biol Chem. 2008, 283, 21284-93.

4. "Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)", Zhang L, Liu W, Hu T, Du L, Luo C, Chen K, Shen X*, Jiang HL*,J Biol Chem. 2008, 283, 5370-5379.

5."Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations", Chen S, Chen L, Tan J, Chen J, Du L, Sun T, Shen J, Chen K, Jiang HL*, Shen X*, J Biol Chem. 2005, 280, 164-173.

6. "Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro", Chen L, Gui C, Luo X, Yang Q, Günther S*, Scandella E, Drosten C, Bai D, He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, Thiel V, Chen K, Shen J, Shen X*, Jiang HL, J. Virol. 2005, 79, 7095-7103.

7. "Virtual screening on natural products for discovering active compounds and target information", Shen J, Xu X, Cheng F, Liu H, Luo X, Shen J, Chen K, Zhao W, Shen X*, Jiang HL*, Curr Med Chem. 2003, 10, 2327-42.

8. "An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development", Chen S, Luo H, Chen L, Chen J, Shen J, Zhu W, Chen K, Shen X*, Jiang HL*, Curr Pharm Des. 2006, 12, 4539-4553.

9. "Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction", Luo H, Wu D, Shen C, Chen K, Shen X*, Jiang HL, Int J Biochem Cell Biol. 2006, 38, 589-599.

10."Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARgamma", Zou G, Gao Z, Wang J, Zhang Y, Ding H, Huang J, Chen L, Guo Y, Jiang H, Shen X*, Biochem Pharmacol. 2008, 75, 1381-1392.