张辰 博士

E-mail: czhang@ecust.edu.cn

地址：华东理工大学 徐汇校区实验十八楼1513

教育经历

2015/10-2018/09   图卢兹大学，化学专业，理学博士，导师：Heinz Gornitzka

2011/09-2014/06   华东理工大学，药学专业，医学硕士，导师：徐玉芳

2007/09-2011/06   华东理工大学，制药工程，工学学士

科研与学术工作经历

2019/01-至今    华东理工大学，药物科学系，博士后，合作导师：李洪林

2018/09-2018/12   法国国家科学研究中心药理与结构生物学研究所，博士后，合作导师：Olivier Cuvillier

2014/07-2015/09   中国科学院上海有机化学研究所，生命有机国家重点实验室马大为课题组，研究助理

代表性研究成果

期刊论文

(1) Chen Zhang; Pierre-Yves Fortin; Guillaume Barnoin; Xue Qin; Xing Wang; Alvaro Fernandez Alvarez; Christian Bijani; Marie-Lise Maddelein; Catherine Hemmert; Olivier Cuvillier; and Heinz Gornitzka. An Artemisinin-Derivative–(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity. Angewandte Chemie International Edition, 2020, 59: 2~9

(2) Chen Zhang; Marie-Lise Maddelein; Raymond Wai-Yin Sun; Heinz Gornitzka; Olivier Cuvillier; Catherine Hemmert, Pharmacomodulation on Gold-NHC complexes for anticancer applications is lipophilicity the key point?,European Journal of Medicinal Chemistry, 2018, 157: 320~332

(3) Chen Zhang; Sandra Bourgeade Delmas; Alvaro Fernandez Alvarez; Alexis Valentin; Catherine Hemmert; Heinz Gornitzka,Synthesis, characterization,and antileishmanial activity of neutral N-heterocyclic carbenes gold(I)complexes, European Journal of Medicinal Chemistry, 2017, 143: 1635~1643

(4) Chen Zhang; Catherine Hemmert; Heinz Gornitzka; Olivier Cuvillier; Ming Zhang; Raymond Wai-Yin Sun,Cationic and Neutral N-HeterocyclicCarbene Gold(I) Complexes: Cytotoxicity, NCI-60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen SpeciesFormation, ChemMedChem, 2018, 13: 1~13

(5) Rui Gao; Sha Liao; Chen Zhang; Weilong Zhu; Liyan Wang; Jin Huang; Zhenjiang Zhao; Honglin Li; Xuhong Qian; Yufang Xu,Optimization ofheterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IXinhibitors and their structure activity relationship, European Journal of Medicinal Chemistry, 2013, 62: 597~604

(6) Changlong Wang; Jimena Tuninetti; Zhao Wang; Chen Zhang; Roberto Ciganda; Lionel Salmon; Sergio Moya; Jaime Ruiz; Didier Astruc,Hydrolysis ofAmmonia-Borane over Ni/ZIF 8 Nanocatalyst: High Efficiency, Mechanism, andControlled Hydrogen Release, Journal of the American Chemical Society, 2017, 139 (33): 11610~11615

授权发明专利

（1）马大为，俞强; 袁钧瑛; 夏宏光; 蔡东坡; 王开亮; 张辰; 夏尚华, EGFR激酶抑制剂及其制备方法和应用, 2017.3.30-2037.3.29, WIPO, WO 2017/049992 Al

（2）李洪林; 徐玉芳; 赵振江; 黄瑾; 高瑞; 王立言; 张辰; 朱伟龙; 杨春梅, 苯磺酰胺类化合物及其用途, 2012.10.3-2032.10.2, 中国, CN102702109A

（3）徐玉芳; 赵振江; 黄瑾; 朱维平; 刘莉; 王立言; 杨春梅; 朱伟龙; 张辰; 李洪林, 磺酰胺类化合物及其用途, 2012.10.3-2032.10.2, 中国, CN102702057A