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朱维平 教授  博士生导师


电话:  021-64253822

传真:  021-64252603
地址: 上海市梅陇路130号华东理工大学实验18楼1507室
E-mail: wpzhu@ecust.edu.cn  
 

个人简介

朱维平，男，1967年生于江苏扬中。1989.7毕业于国防科技大学应用化学专业，获工学学士学位，1992.7毕业于华东化工学院(现华东理工大学)精细化工专业，获工学硕士学位，2004.6毕业于华东理工大学化学工程专业，获工学博士学位。1992.7-1999.9扬子石化研究院工程师、副所长；1999.10-2005.1扬子石化研究院高级工程师、副所长、所长；2005.2-2010.8，华东理工大学药学院副教授, 2010.9至今，华东理工大学教授，博士生导师。2009-2010，美国加州大学洛杉矶分校访问学者；2016.2-2016.8，美国斯坦福大学医学院访问学者。作为负责人先后承担上海市市级科技重大专项、国家自然科学基金项目、国家“863”计划项目、国家科技支撑计划课题、上海市浦江人才计划项目、上海市科委重点攻关项目、上海市科委基础研究重点项目等。 2007年至今，已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem Eng J., Theranostics, Chem. Commun., J. Mater. Chem., Int. J. Pharmaceut.等国际著名学术刊物上发表 SCI 论文100余篇，申请中国发明专利20余项，授权13项。

 

研究方向


（一）药物连续流动合成。针对药物制造过程中面临的安全、环保及成本等瓶颈，开展药物连续流动合成技术及反应动力学研究，研制新一代微纳化工反应器。

（二）新型药物控制释放系统的构建。针对生物大分子药物（如胰岛素、抗体药物、siRNA等）、难溶性药物的体内输送，以介孔氧化硅纳米粒子、聚合物纳米凝胶等为载体，设计各类微环境和/或刺激响应型控制释放系统，实现药物分子的可控、靶向给药。

（三）荧光探针及其在生物分析、医学诊断及环境监测中的应用。针对环境及生物体系中各种离子、小分子、生物大分子（酶、蛋白质等），开展高选择性、高灵敏性荧光分子探针的设计、合成及应用研究。 

 

代表性论文


1. Yuejia Ji, Yuxin Sun, Mingyang Hei, Di Cheng, Bin Wang, Yao Tang, Yun Fu, Weiping Zhu,* Yufang Xu, Xuhong Qian. NIR Activated Upper Critical Solution Temperature Polymeric Micelles for Trimodal Combinational Cancer Therapy. Biomacromolecules 2022, 23, 3, 937–947.

2.  Yun Fu, Yuxin Sun, Meng Chen, Wenqian Xing, Yufang Xu, Xuhong Qian, and Weiping Zhu*, Glycopolymer Nanoparticles with On-Demand Glucose-Responsive Insulin Delivery and Low-Hypoglycemia Risks for Type 1 Diabetic Treatment. Biomacromolecules, 2022, 23, 3, 1251–1258.

3. Tongxia Jin，Di Cheng，Guanyu Jiang，Wenqian Xing，Peiwen Liu，Bin Wang，Weiping Zhu*，Haitao Sun*，Zhenrong Sun, Yufang Xu，Xuhong Qian* . Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy. Bioactive Materials, 2022, 14, 42-51.

4.  Rongkun Jiang, Xiao Xue, Fang Zhao, Weiping Zhu*, Minjing Shang, Yuanhai Su*, Yufang Xu, Xuhong Qian. Process parameter and kinetic study for the azidation of a zidovudine intermediate with sodium azide in microreactors. Chemical Engineering Journal, 2022, 429, 132207.

5.  Tongxia Jin, Mengyu Cui, Dan Wu, Weiping Zhu*, Yufang Xu, Xuhong Qian. NCL-based mitochondrial-targeting fluorescent probe for the detection of Glutathione in living cells. Chinese Chemical Letters, 2021, 32, 3899-3902.

6.  Yun Fu, Peng Liu, Meng Chen, Tongxia Jin, Huijing Wu, Mingyang Hei, Congrong Wang, Yufang Xu, Xuhong Qian, Weiping Zhu*. On-demand transdermal insulin delivery system for type 1 diabetes therapy with no hypoglycemia risks. Journal of Colloid and Interface Science 605 (2022) 582–591.

7. Di Cheng , Yuejia Ji , Bin Wang , Tongxia Jin , Yufang Xu , Xuhong Qian , Weiping Zhu*. Enzyme/GSH dual-responsive biodegradable nanohybrid for spatiotemporally specific photodynamic and hypoxia-augmented therapy against tumors. International Journal of Pharmaceutics, 603(2021)120730

8. Di Cheng, Yuejia Ji, Bin Wang, Yuyu Wang, Yao Tang, Yun Fu, Yufang Xu, Xuhong Qian, Weiping Zhu*, Dual-responsive nanohybrid based on degradable silica-coated gold nanorods for triple-combination therapy for breast cancer. Acta Biomaterialia. 128(2021)435-446.

9. Liyang Cui, Arvin M. Gouw, Edward L. LaGory, Shenghao Guo, Nabeel Attarwala, Yao Tang, Ji Qi, YunSheng Chen, Zhou Gao, Kerriann M. Casey, Arkadiy A. Bazhin, Min Chen, Leeann Hu, Jinghang Xie, Mingxi Fang, Cissy Zhang, Qihua Zhu, Zhiyuan Wang, Amato J. Giaccia, Sanjiv Sam Gambhir, Weiping Zhu, Dean W. Felsher, Mark D. Pegram, Elena A. Goun, Anne Le, Jianghong Rao*, Mitochondrial copper depletion suppresses triple-negative breast cancer in mice. Nature Biotechnology, 2021, 39, 357–367.

10. Xiaoqin Wei, Tongxia Jin, Chusen Huang*, Nengqing Jia, Weiping Zhu*, Yufang Xu, Xuhong Qian, Monoarsenical-based chemical approaches for exploration of endogenous vicinal-dithiol-containing proteins (VDPs): From the design to their biological application, Coordination Chemistry Reviews, 2021, 429, 213621-213639.

11. Tongxia Jin, Chusen Huang*, Mengyu Cui, Yonghui Yang, Zhuo Wang, Weiping Zhu*，Xuhong Qian, Supramolecular ensembles modified by near-infrared dyes and their biological applications，Journal of Materials Chemistry B, 2020, 8(47), 10686-10699.

12. Yuyu Wang, Houna Duan, Hongyuan Shi, Shiwei Zhang, Yufang Xu, Weiping Zhu*, Xuhong Qian. A highly sensitive fluorescent probe for tracking intracellular zinc ions and direct imaging of prostatic tissue in mice, Chinese Chemical Letters, 2020, 31, 2933-2936.

13. Yao Tang, Yuejia Ji, Chenglin Yi, Di Cheng, Bin Wang, Yun Fu, Yufang Xu, Xuhong Qian, Yahya E. Choonara, Viness Pillay, Weiping Zhu*, Yunen Liu, Zhihong Nie*. Self-accelerating H2O2-responsive plasmonic nanovesicles for synergistic chemo/starving therapy of tumors, Theranostics, 2020, 10(19), 8691-8704.

14. Mingyang Hei, Huijing Wu, Yun Fu, Yufang Xu, Weiping Zhu*. Phenylboronic acid functionalized silica nanoparticles with enlarged ordered mesopores for efficient insulin loading and controlled release. Journal of Drug Delivery Science and Technology, 2019, 51(3), 320-326.

15. Yao Tang, Hongyuan Shi, Di Cheng, Jing Zhang, Yuncheng Lin, Yufang Xu, Xuhong Qian, WeipingZhu*. pH-Activatable tumor-targeting gold nanoprobe for near-infrared fluorescence/CT dual-modal imaging in vivo. Colloids and Surfaces B: Biointerfaces, 2019, 179(7), 56-65.

16. Houna Duan, Yu Ding, Chusen Huang,* Weiping Zhu*, Rui Wang, Yufang Xu. A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells. Chinese Chemical Letters, 2019, 30(1), 55-57.

17. Yuezheng Ti, Ling Yu, Yao Tang, Tongxia Jin, Ming Yang, Rui Wang*, Yufang Xu, Weiping Zhu*. A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation, Sensors and Actuators B: Chemical, 2018, 265, 582-590.

18. Huijing Wu, Junhua Jia, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable bifunctional fluorescent sensor for the detection and removal of silver ions in aqueous solutions, Sensors and Actuators B: Chemical, 2018, 265, 59-66.

19. Mingyang Hei, Jun Wang, Kelly Wang, Weiping Zhu* and Peter X Ma*. Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery, Journal of Materials Chemistry B, 2017, 5, 9497-9501.

20. Feng Yu, Huijing Wu, Yao Tang, Yufang Xu, Xuhong Qian, and Weiping Zhu*. Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system, International Journal of Pharmaceutics, 2018, 536, 11-20.

21. Xiaotong Jia, Qiangqiang Chen, Yingfang Yang, Yao Tang, Rui Wang, Yufang Xu, Weiping Zhu, Xuhong Qian*. A FRET-based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5, Journal of American Chemistry Society, 2016, 138 (34), 10778–10781.

22. Jingwen Zhang, Chao Wang, Lei Zhang, Huijing Wu, Yi Xiao,* Yufang Xu, Xuhong Qian and Weiping Zhu*. Novel nonplanar and rigid fluorophores with intensive emission in water and the application in two-photon imaging of live cells, RSC Advances, 2016, 6, 71624-72627.

23. Yujie Li, Mingyang Hei, Yufang Xu, Xuhong Qian, Weiping Zhu*. Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery, International Journal of Pharmaceutics, 2016, 511, 689-702.

24. Qi Cai, Gaosheng Liang, Yufang Xu, Xuhong Qian*, and Weiping Zhu*. A Reusable Heterogeneous Catalyst without Palladium Leaking for High-efficient Suzuki-Miyaura Reaction in Pure Water under Air, RSC Advances, 2016, 6, 60996-61000.

25. Yao Tang, Yu Liu, Yiqiao Qin, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable thioether-rich crown-based fluorescent sensor for the detection and removal of mercuric ions, Journal of Colloid and Interface Science, 2016, 479, 7-14.

26. Junhua Jia, Luling Wu, Yu Ding, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. A DPA-based highly selective and sensitive fluorescent probe for mercuric ions and its imaging in living cells, Dalton Transactions, 2016, 45, 9402-9406

27. Mengfang Tang, Luling Wu, Dan Wu, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. An “Off-On” Fluorescent Probe for the Detection of Cysteine /Homocysteine and Its Imaging in Living Cells, RSC Advances, 2016, 6(41), 34996-35000

28. Qi Cai, Tao Yu, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A turn-on fluorescent probe for tumor hypoxia imaging in living cells, Chemical Communications, 2015, 51(79), 14739-14741.

29. Chunsheng He, Long Ren, Weiping Zhu*, Yufang Xu, and Xuhong Qian*. Removal of mercury from aqueous solution using mesoporous silica nanoparticles modified with polyamide receptor, Journal of Colloid and Interface Science, 2015, 458(1), 229-234.

30.  Yu Ding, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A small molecular fluorescent sensor functionalized silica microsphere for detection and removal of mercury, cadmium, and lead ions in aqueous solutions, Sensors and Actuators B: Chemical, 2015, 220(1), 762-771.

31. Yuanyuan Luo, Dan Tang, Weiping Zhu, Yufang Xu and Xuhong Qian*. Reactive fluorescent dye functionalized cotton fabric as a Magic Cloth'' for selective sensing and reversible separation of Cd2+ in water, Journal of Materials Chemistry C, 2015, 3, 8485-8489.

32. Tiantian Chen, Liyan Yin, Chusen Huang*, Yiqiao Qin, Weiping Zhu*, Yufang Xu, and Xuhong Qian, Highly selective “off-on” fluorescent probe for histidine and its imaging in living cells, Biosensors and Bioelectronics, 2015, 66(1), 259-265.

33. Chusen Huang, Ti Jia, Mengfang Tang, Qin Yin, Weiping Zhu*, Chao Zhang, Yi Yang,Nengqin Jia*, Yufang Xu*, Xuhong Qian. Selective and Ratiometric Fluorescent Trapping and Quantification of Protein Vicinal Dithiols and In Situ Dynamic Tracing in Living Cells, Journal of American Chemistry Society, 2014,  136 (40), 14237–14244.