高峰 教授，博导
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电话: 021-6425-2449
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传真:
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E-mail: fgao@ecust.edu.cn
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个人简介
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2001年日本国立千叶大学药学院获药学博士学位，2001－2002.3在日本千叶大学药学院作博士后，从事抗肿瘤药物与内源性氧自由基的关系，及其所引起消化管毒性机制的研究工作。2002－2004.3在日本国立大阪大学微生物病研究所进行博士后研究，从事抗肠道传染病功能高分子微球－抗体复合体制剂的研究工作。2004年5月受聘于华东理工大药学院，副教授，教授。现任药物制剂专业责任教授。主要研究方向为分子生物药剂学和毒理学。先后承担了“上海市引进海外高层次留学人员专项资金”等科研项目10项。曾获得美国FIP颁布的“优秀研究论文”、日本药学会颁布的“长井优秀论文”、“第四届药物制剂论坛”优秀青年报告奖等多项国际学会奖项。发表学术论文70余篇，申请专利6项，其中2项授权。
研究方向
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现主要研究领域：
分子生物药剂学研究、毒理学研究
现主要研究方向：
1、新型微粒给药系统的构建及体内外功效评价
2、多尺度纳米颗粒生物安全性评价体系研究
3、药物制剂开发与药物动力学研究
获奖成果
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1）在2001年日本薬剤学会第16年会学会中荣获日本药学会颁布的“长井优秀论文奖”
2）在2000年世界药学学会中荣获有美国FIP颁布的“优秀研究论文奖”
3）在2009年第四届国际药物制剂论坛中荣获“青年报告奖”
代表性论著
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1. Yuan ZT, Ye YJ, Gao F*, Yuan HH, Lan MB, Lou KY, Wang W. Chitosan-graft-β-cyclodextrin nanoparticles as a carrier for controlled drug release. Int J Pharm. 2013, 446: 191-198.
2. 陈水娟, 付栋君, 高姗姗, 高峰*, 左建平. 难溶性药物BMCP25 二甲基-β- 环糊精包合物的表征及在大鼠体内的药动学. 中国医药工业杂志. 2013, 44 (2): 171-174.
3. 陈香, 姚芳, 陈水娟, 方源, 高峰*, 钟建江. 灵芝酸单体 T 片剂的制备及其兔体内药动学研究. 中国药学杂志. DOI: 10. 11669/ cpj. 2013. 12.00?
4. Gao SS, Sun J, Fu DJ, Zhao HL, Lan MB, Gao F*. Preparation, characterization and pharmacokinetic studies of tacrolimus-dimethyl-β-cyclodextrin inclusion complex-loaded albumin nanoparticles. Int J Pharm. 2012, 427: 410-416.
5. Shen Q,Gao SS, Gao F*. Curative effect of novel oral carbon microspheres on streptozotocin induced diabetes mellitus in rats. J Chin Pharm Sci. 2012, 21: 234-241.
6. Wang F, Gao F*. Oxidative mechanisms contribute to nanosize silican dioxide-induced developmental neurotoxicity in PC12 cells. Toxicol In Vitro. 2011, 25: 1548-1556.
7. Xie YN, Gao F*. Preparation of a novel activated carbon microsphere and its in vitro adsorption characteristics for biological molecules. J Chin Pharm Sci. 2011, 20: 303-308.
8. Jiang ZJ, Jin TT, Gao F, Liu JW *,Zhong* JJ, Zhao H*. Effects of ganoderic acid Me on inhibiting multidrug resistance and inducing apoptosis in multidrug resistant colon cancer cells. Process Biochem, 2011, 46: 1307-1314.
9. 高原, 蔡轶军, 高峰*.硫酸氢氯吡格雷片处方和制备工艺研究. 中国药学杂志, 2011, 46(2): 117-123.
10. 陶少林, 陈香, 钟建江, 高峰*. 灵芝酸单体Me肠溶胶囊制备及其兔体内生物利用度测定. 中成药. 2011, 33 (6): 950-954.
11. Sun Y, Gu L, Gao Y, Gao F*.Preparation and characterization of 5-fluorouracil loaded chitosan microspheres by a two-step solidification method. Chem Pharm Bull. 2010, 58: 891-895.
12. Chen X, Tao SL, Gao F*, Zhong JJ. Quantitative determination of ganoderic acid T in rat plasma by a sensitive RP-HPLC method and its pharmacokinetic studies. J Chin Pharm Sci. 2010, 19: 171-175.
13. 杨春梅, 顾磊, 孙怡, 施竟成, 乐子娜, 高峰*. 离子交联法制备氟尿嘧啶壳聚糖微球的研究. 华东理工大学学报. 2010, 36: 546-549.
14. 杨春梅, 顾磊, 孙怡, 孙军, 高峰*. 戊二醛一步固化法制备5-氟尿嘧啶壳聚糖微球制剂的研究.中国医药工业杂志. 2010, 41(1): 23-26.
15. Xu K, Liang X, Gao F, Zhong JJ, Liu JW. Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion. Process Biochem. 2010, 45: 1261-1267.
16. Yuan HH, Gao F, Zhang ZG, Miao LD, Yu RH, Zhao HL, Lan MB. Study on controllable preparation of silica nanoparticles with multi-sizes and their size-dependent cytotoxicity in pheochromocytoma cells and human embryonic kidney cells. J Health Sci. 2010, 56: 632-640.
17. Zhao HL, Zhang JF, Gao F, Lan MB. Synthesis, spectral properties and cell assays of novel fluorophore-modified-β-cyclodextrin derivatives. Adv Sci Lett. 2010, 3: 1-6.
18. Lan MB, Zhang YH, Zheng Y, Yuan HH, Zhao HL, Gao F. Antioxidant and immunomodulatory activities of polysaccharides from moxa (Artemisia argyi) leaf. Food Sci Biotechnol. 2010, 19: 1463-1469.
19. Wang F, Gao F*, Lan MB, Yuan HH, Huang YP, Liu JW. Oxidative stress contributes to silica
nanoparticle-induced cytotoxicity in human embryonic kidney cells. Toxicol In Vitro. 2009, 23: 808-815.
20. 陶少林, 钟建江, 高峰*.高效液相色谱法测定大鼠全血中的灵芝酸单体Me. 现代仪器. 2009, 15(1):26-28.
21. 李艾斯,黄永平, 刘建文, 蓝闽波, 高峰. 药用纳米SiO2 对人正常肺细胞的氧化损伤. 中国临床药理学与治疗学. 2009, 14(10), 1115-1120.
22. Gao F, Kodama T, Chen XH, Okada K, Honda K. A targeting approach for delivery of polymer microparticle-antibody conjugate against Vibrio parahaemolyticus - induced cytotoxicity to human intestinal epithelial cells. J Drug Target. 2007, 15 (6): 428-36.
23. 万晓璐, 王苏莉, 高峰, 崔景斌. 避蚊胺缓释霜剂的研制及其体外的经皮渗透.华西药学杂志. 2007, 22(2), 174-176.
24. 陶一丹, 谢毅妮, 腾娜, 高峰. 新型口服活性炭微球对内源性分子肌酐的吸附性能研究. 广州化工. 2007, 35(5), 32-35.
25. Ren F, Jing Q, Tang Y, Shen Y, Chen J, Gao F, Cui J. Characterization of bicalutamide solid dispersions and improvement of the dissolution. Drug Dev Ind Pharm. 2006, 32(8): 967-72.
26. Miyazono Y, Gao F, Horie T. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand J Gastroenterol. 2004, 39: 1119-27.
27. Sosogi A, Gao F, Tomimatsu T, Hirata K, Horie T. Non-steroidal anti-inflammatory drugs affect the methotrexate transport in IEC-6 cells. Life Sci. 2003, 73 (4): 437-46.
28. Sosogi A, Gao F, Tomimatsu T, Hirata K, Horie T. Effects of non-steroidal anti- inflammatory drugs on the methotrexate transport in rat small intestine. Scand J Gastroenterol. 2003, 38(1):43-9.
29. Gao F, Tomitori H, Igarashi K, Horie T. Correlation between methotrexate-induced intestinal damage and decrease in polyamine content. Life Sci. 2002, 72 (6): 669-76.
30. Gao F, Horie T. A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats. Life Sci. 2002, 71(9):1091-9.
31. Gao F, Nakamaru M, Masubuchi Y, Horie T. Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats. J Pharm Sci. 2001, 90(8):1040-8.
32. Gao F, Ueda S, Horie T. Effect of a synthetic analog of prostaglandin E1 on the intestinal mucosa of methotrexate-treated rats. Anticancer Res. 2001, 21 (3B):1913-7.
33. Gao F, Horie T. Protective effect of prostaglandins on the methotrexate induced damage of small intestine in rats.
In Vivo. 2000, 14(3):453-6.
发明专利
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1. 高峰, 孙怡, 蓝闵波, 赵红莉, 曹海, 付栋君. 一种脑靶向基头修饰性环糊精衍生物的合成方法. 中国专利: 201010266055.9, 2010-08-25.
2. 高峰, 钟建江, 陶少林, 谢旖旎, 王芬, 孙军, 孙怡, 陈香,李英波, 王家乐. 灵芝酸单体Me环糊精包合物及其口服固体制剂的制备方法. 中国专利: 200910050801.8, 2009-05-08.
3. 高峰, 等. 一种灵芝酸单体T片剂及其制备方法. 中国专利: 201010501013.9.
4. 高峰, 等. 一种二氧化硅纳米颗粒细胞生物安全性的评价方法. 中国专利: 200910196617.4
5. 杜一平, 高峰, 等. 一种直接植入式微透析探针及其制备方法. 中国专利: 200910195763.5.
6. 蓝闵波, 高峰, 等. 艾叶多糖的临床前研究. 中国专利: 08DZ1974000.
